N,N'-Diacetylglycine anhydride
N,N'-Diacetylglycine anhydride
CAS: 3027-05-2
Molecular Formula: C8H10N2O4
N,N'-Diacetylglycine anhydride - Names and Identifiers
| Name | N,N'-Diacetylglycine anhydride |
| Synonyms | N,N'-Diacetylglycine anhydride N,N'-DIACETYLGLYCINE ANHYDRIDE 1,4-DIACETYL-2,5-DIOXOPIPERAZINE 1,4-DIACETYL-2,5-PIPERAZINEDIONE 1,4-DIACETYL-2,5-DIKETOPIPERAZINE 1,4-Diacetyl-piperazine-2,5-dione 1,4-Diacetyl-2,5-diketopiperazine 1,4-DIACETYL-PIPERAZINE-2,5-DIONE N,N′-Diacetyl-2,5-dioxopiperazine 2,5-Piperazinedione, 1,4-diacetyl- 1,4-DIACETYLTETRAHYDRO-2,5-PYRAZINEDIONE |
| CAS | 3027-05-2 |
| InChIKey | CBBKKVPJPRZOCM-UHFFFAOYSA-N |
N,N'-Diacetylglycine anhydride - Physico-chemical Properties
| Molecular Formula | C8H10N2O4 |
| Molar Mass | 198.18 |
| Density | 1.375±0.06 g/cm3(Predicted) |
| Melting Point | 99-100°C |
| Boling Point | 424.4±38.0 °C(Predicted) |
| Flash Point | 216.6 °C |
| Appearance | powder to crystal |
| Color | White to Light yellow to Light orange |
| BRN | 188115 |
| pKa | -1.74±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD00059789 |
N,N'-Diacetylglycine anhydride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact R36/38 - Irritating to eyes and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
N,N'-Diacetylglycine anhydride - Reference Information
| Introduction | 1, 4-diacetylpiperazine -2, 5-dione is also called diacetylated glycylglycine, which can be obtained by acylation of glycylglycine and acetic anhydride. 1, 4-diacetylpiperazine -2, 5-dione can be used to prepare DL-neopentylglycine derivatives. |
| application | 1, 4-diacetylpiperazine -2, 5-dione can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical medicine synthesis process. |
| preparation | first weigh 80g of glycylglycine and 80g of acetic anhydride, add glycylglycine to acetic anhydride solution for dissolution, raise the temperature at 120 ℃, reflux for 4h, after the reaction is finished, concentrate the reaction liquid in vacuum to dry 116g of oil, add 232g of ethyl acetate to dissolve, filter to remove salt, then concentrate the obtained filtrate in vacuum, slowly add 232g of petroleum ether, add petroleum ether while stirring and beating, then suction filtration, drying, the intermediate diacetylated glycine 163g. |
Last Update：2024-04-09 21:04:16
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